GPT-4b adding years

Plus: AI and tech job offers

Author

Martin Musiol
September 01, 2025 • Estimated Reading Time: 4 minutes

Hello Friends!
This is a quick one: OpenAI’s special LLM GPT-4b, which is a gift to humanity.

And, I might have access to a bunch of great AI Jobs. Are you interested in receiving?

Download our guide on AI-ready training data.

AI teams need more than big data—they need the right data. This guide breaks down what makes training datasets high-performing: real-world behavior signals, semantic scoring, clustering methods, and licensed assets. Learn to avoid scraped content, balance quality and diversity, and evaluate outputs using human-centric signals for scalable deployment.

(✨ If you don’t want ads like these, Premium is the solution. )

OpenAI’s GPT-4b

(Source)

GPT-4b is a specialized LLM developed by OpenAI in partnership with Retro Biosciences, a startup focused on anti-aging research. It's a fine-tuned version of OpenAI's GPT-4 series, optimized for biotechnology applications.

What Does It Do?

In simple terms, GPT-4b acts like a "protein engineer." It analyzes biological data, such as protein sequences, to predict how proteins interact and suggest modifications. For example, it can redesign proteins to make it easier to turn ordinary cells into stem cells, which are versatile cells that can develop into various tissues.

It is being done via Yamanaka factors. 

Yamanaka factors (OCT4, SOX2, KLF4, MYC) are proteins that reprogram adult cells into versatile stem cells for regenerative medicine. GPT-4b micro redesigned SOX2 and KLF4 into enhanced versions (RetroSOX, RetroKLF), boosting reprogramming efficiency by over 50x, speeding up the process, and improving DNA damage repair for better longevity therapies.

Why It Matters

Imagine a world where aging slows to a crawl: GPT-4b's protein wizardry could unlock vibrant futures by turbocharging biotech breakthroughs. Concrete benefits:

  • Regenerative Therapies: Faster, cheaper stem cell production to repair damaged hearts or brains, mending injuries like never before.

  • Disease Treatments: Tailored proteins to combat Alzheimer's, cancer, or diabetes, slashing treatment times from years to months.

  • Lifespan Extension: Enhanced cellular reprogramming might add 10–20 healthy years, letting people thrive longer with youthful vitality.

  • Drug Discovery Speedup: AI-designed molecules hit the market quicker, making personalized meds affordable and widespread.

Most Impactful One: Lifespan extension stands out as transformative—it could redefine human potential, easing global healthcare burdens and sparking a renaissance in productivity and innovation.

And btw. Google DeepMind is also working in this field.

Google DeepMind's AlphaFold predicts 3D protein structures and AlphaProteo designs novel proteins for drug development, supporting longevity research but not directly targeting Yamanaka factors like GPT-4b micro.

AI Job Offers (some GenAI)

Would you like exclusive AI and tech job offers?

Something is cooking in the back.

Login or Subscribe to participate in polls.

I hope you enjoyed it.

Happy weekend!
🙇Martin

Our webpage